Proteomics

Dataset Information

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DNA repair proximity landscape analysis reveals shieldin as a key regulator of NHEJ-dependent processes


ABSTRACT: By combining proximity labeling with quantitative mass spectrometry, we generated high-resolution interaction neighborhood maps of the endogenously expressed DNA repair factors 53BP1, BRCA1, and MDC1.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Rajat Gupta  

LAB HEAD: Chunaram Choudhary

PROVIDER: PXD009284 | Pride | 2018-04-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Apex-53BP1Exp1-1.raw Raw
Apex-53BP1Exp1-2.raw Raw
Apex-53BP1Exp1-3.raw Raw
Apex-53BP1Exp1-4.raw Raw
Apex-53BP1Exp1-5.raw Raw
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Publications

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

Gupta Rajat R   Somyajit Kumar K   Narita Takeo T   Maskey Elina E   Stanlie Andre A   Kremer Magdalena M   Typas Dimitris D   Lammers Michael M   Mailand Niels N   Nussenzweig Andre A   Lukas Jiri J   Choudhary Chunaram C  

Cell 20180412 4


Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining proximity labeling with quantitative mass spectrometry, we generated high-resolution interaction neighborhood maps of the endogenously expressed DNA repair factors 53BP1, BRCA1, and MDC1. Our spatially resolved interaction maps reveal rich network intricacies, identify shared and bait-specific interaction modules, and implicate previously con  ...[more]

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