Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell, Epithelial Cell
DISEASE(S): Age Related Macular Degeneration
SUBMITTER: Bincui Cai
LAB HEAD: Xiaorong Li
PROVIDER: PXD009309 | Pride | 2022-02-22
REPOSITORIES: pride
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Translational vision science & technology 20220201 2
<h4>Purpose</h4>The aim of this study was to explore whether there are interactions between genetic (ARMS2/HTRA1) and environmental factors (cigarette smoking) in the pathogenesis of age-related macular degeneration (AMD).<h4>Methods</h4>Primary human retinal pigment epithelial (hRPE) cells were obtained from four donors' eyes with AMD high-risk ARMS2/HTRA1 alleles, and two donors' eyes with wild-type alleles were used as controls. The pooled serum from 32 smokers and 35 nonsmokers were collecte ...[more]