Proteomics

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Deep proteomic analysis of murine erythroid differentiation

ABSTRACT: Erythropoiesis is a tightly controlled process. Although human and murine erythropoiesis are grossly similar, several aspects of these processes present significant differences. We have performed a label free quantification of proteins expressed during murine erythroid differentiation of primary cells with the aim to compare human and murine differentiations. Furthermore, we also analyzed the proteome of three murine cell lines, MEDEP, G1ER and Friend cells, to determine their similarities with the proteome of primary cells.

OTHER RELATED OMICS DATASETS IN: GSE120379

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Erythroid Lineage Cell, Cell Culture, Bone Marrow

SUBMITTER: Emilie-Fleur GAUTIER  

LAB HEAD: Patrick MAYEUX

PROVIDER: PXD009384 | Pride | 2020-05-26

REPOSITORIES: Pride

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Dataset's files

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MeLA170503_WT_M1_0h_SCX1_Q20534_170511214912.raw Raw
MeLA170503_WT_M1_0h_SCX2_Q20535_170512004328.raw Raw
MeLA170503_WT_M1_0h_SCX3_Q20536_170512033747.raw Raw
MeLA170503_WT_M1_0h_SCX4_Q20537_170512063204.raw Raw
MeLA170503_WT_M1_0h_SCX5_Q20538_170512092620.raw Raw
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Publications

Murine-based cellular models have provided and continue to provide many useful insights into the fundamental mechanisms of erythropoiesis, as well as insights into the pathophysiology of inherited and acquired red cell disorders. Although detailed information on many aspects of these cell models is available, comprehensive proteomic data are lacking. This is a critical knowledge gap, as proteins are effectors of most biologic processes. To address this critical unmet need, proteomes of the murin  ...[more]

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