Proteomics

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Characterization of a nonhuman primate model for the study of testicular peritubular cells – comparison with human testicular cells

ABSTRACT: Smooth-muscle-like peritubular cells make up the wall of semniferous tubules of men. These human testicular peritubular cells (HTPC) have been shown to fulfill different roles. They transport sperm, secrete various factors like GDNF (glial cell line derived neurotrophic factor) and are immunologically active. They might contribute to spermatogonial stem cell niche altering and testicular ageing. Previous studies were limited regarding heterogeneity (due to lifestyle, age, medical history etc.) and accessibility of HTPCs. To circumvent this problem a cellular primate model should be established. The proteome of 6 MKTPCs of individual healthy and young (2 or 3 years) donors was assessed to investigate the suitability as a model.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Callithrix Jacchus

TISSUE(S): Testis, Primary Cell, Peritubular Myoid Cell

SUBMITTER: Jan Bernd Stöckl  

LAB HEAD: Georg J. Arnold

PROVIDER: PXD009394 | Pride | 2018-06-06

REPOSITORIES: Pride

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170324_MKTPC1.wiff Wiff
170324_MKTPC1.wiff.scan Wiff
170324_MKTPC2.wiff Wiff
170324_MKTPC2.wiff.scan Wiff
170324_MKTPC3.wiff Wiff
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Characterization of a non-human primate model for the study of testicular peritubular cells-comparison with human testicular peritubular cells.

Schmid N N   Stöckl J B JB   Flenkenthaler F F   Dietrich K-G KG   Schwarzer J U JU   Köhn F-M FM   Drummer C C   Fröhlich T T   Arnold G J GJ   Behr R R   Mayerhofer A A  

Molecular human reproduction 20180801 8

<h4>Study question</h4>Are monkey testicular peritubular cells (MKTPCs) from the common marmoset monkey (Callithrix jacchus) a suitable translational model for the study of human testicular peritubular cells (HTPCs)?<h4>Summary answer</h4>MKTPCs can be isolated and propagated in vitro, retain characteristic markers for testicular peritubular cells and their proteome strongly (correlation coefficient of 0.78) overlaps with the proteome of HTPCs.<h4>What is known already</h4>Smooth-muscle-like per  ...[more]

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