Dataset Information

TMT-based quantitative proteomics of plasma from chicken challenged with lipopolysaccharide endotoxin

ABSTRACT: The change in the plasma proteome in chicken (Gallus gallus) challenged with lipopolysaccharide (endotoxin) derived from E. coli was determined by relative quantitation using a TMT label-based approach. This study provides insights into different factors contributing to innate immune response to experimental infection during 72 hours with special emphasis on acute phase proteins (APPs). Apart from APPs, several pathways endopeptidase activation and vasoconstriction were found to be significant.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Blood Plasma

DISEASE(S): Bacterial Infectious Disease

SUBMITTER: Anita Horvatic

LAB HEAD: David Eckersall

PROVIDER: PXD009399 | Pride | 2018-08-20

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20171109_chicken_serum_all.mgf	Mgf
	20171109_chicken_serum_six1.mgf	Mgf
	20171109_chicken_serum_six1.raw	Raw
	20171109_chicken_serum_six2.mgf	Mgf
	20171109_chicken_serum_six2.raw	Raw

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Publications

Quantitative proteomics using tandem mass tags in relation to the acute phase protein response in chicken challenged with Escherichia coli lipopolysaccharide endotoxin.

Horvatić Anita A Guillemin Nicolas N Kaab Haider H McKeegan Dorothy D O'Reilly Emily E Bain Maureen M Kuleš Josipa J Eckersall Peter David PD

Journal of proteomics 20180813

The inflammatory response in chickens (Gallus Gallus domesticus) is an integral part of the bird's response to infection. Detailing proteomic changes occurring during infection would be beneficial to the poultry industry, offering opportunities for comparative pathophysiological analysis. The objective of this study was to quantify the changes in the plasma proteome in chickens challenged with lipopolysaccharide (LPS), a bacterial endotoxin known to stimulate the host innate immune system. Plasm ...[more]

PMID: 30114510

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