Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88
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ABSTRACT: Innate immune cells, and myeloid lineage cells in particular, constitute the first line ofdefense for the containment of invading pathogens. To meet the augmented demand of myeloidcells in response to systemic infections, inflammatory signals trigger a rapid transcriptional response inhematopoietic stem and progenitor cells (HSPCs), promoting their proliferation and preferential differentiation towards the granulocytic lineage
INSTRUMENT(S): LTQ
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Bone Marrow
DISEASE(S): Acute Leukemia
SUBMITTER: Anita Saraf
LAB HEAD: Anita Saraf
PROVIDER: PXD009469 | Pride | 2019-07-12
REPOSITORIES: Pride
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