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Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88

ABSTRACT: Innate immune cells, and myeloid lineage cells in particular, constitute the first line ofdefense for the containment of invading pathogens. To meet the augmented demand of myeloidcells in response to systemic infections, inflammatory signals trigger a rapid transcriptional response inhematopoietic stem and progenitor cells (HSPCs), promoting their proliferation and preferential differentiation towards the granulocytic lineage

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Bone Marrow

DISEASE(S): Acute Leukemia

SUBMITTER: Anita Saraf

LAB HEAD: Anita Saraf

PROVIDER: PXD009469 | Pride | 2019-07-12

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Hs_Control-empty-vec-SPOP_K562-NE_FLAG-IP_Ti_L5_1.mzid.gz	Mzid
	Hs_Control-empty-vec-SPOP_K562-NE_FLAG-IP_Ti_L5_101.RAW	Raw
	Hs_Control-empty-vec-SPOP_K562-NE_FLAG-IP_Ti_L5_101.ms2	Other
	Hs_Control-empty-vec-SPOP_K562-NE_FLAG-IP_Ti_L5_101.pride.mgf.gz	Mgf
	Hs_Control-empty-vec-SPOP_K562-NE_FLAG-IP_Ti_L5_102.RAW	Raw

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