Dataset Information

Major metabolic pathway alterations in the rat myocardium during development of Type 2 diabetes mellitus

ABSTRACT: The understanding of protein alterations in the diabetic heart is of vital importance because of increased risk of cardiovascular co-morbidities. The study aims at elucidating metabolic pathways in the diabetic rat heart during development of Type 2 diabetes mellitus using MS based proteomics.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart

SUBMITTER: Anders Edhager

LAB HEAD: Johan Palmfeldt

PROVIDER: PXD009538 | Pride | 2018-06-26

REPOSITORIES: Pride

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Publications

Proteomics of the Rat Myocardium during Development of Type 2 Diabetes Mellitus Reveals Progressive Alterations in Major Metabolic Pathways.

Edhager Anders Valdemar AV Povlsen Jonas Agerlund JA Løfgren Bo B Bøtker Hans Erik HE Palmfeldt Johan J

Journal of proteome research 20180615 7

Congestive heart failure and poor clinical outcome after myocardial infarction are known complications in patients with type-2 diabetes mellitus (T2DM). Protein alterations may be involved in the mechanisms underlying these disarrays in the diabetic heart. Here we map proteins involved in intracellular metabolic pathways in the Zucker diabetic fatty rat heart as T2DM develops using MS based proteomics. The prediabetic state only induced minor pathway changes, whereas onset and late T2DM caused p ...[more]

PMID: 29847139

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