Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Sharon Pitteri
LAB HEAD: Sharon Pitteri
PROVIDER: PXD009553 | Pride | 2018-09-13
REPOSITORIES: Pride
Action | DRS | |||
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HUMAN.fasta | Fasta | |||
Key.xlsx | Xlsx | |||
MCF10Achalcone_1.raw | Raw | |||
MCF10Achalcone_2.raw | Raw | |||
MCF10Achalcone_3.raw | Raw |
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Going Catherine C CC Tailor Dhanir D Kumar Vineet V Birk Alisha M AM Pandrala Mallesh M Rice Meghan A MA Stoyanova Tanya T Malhotra Sanjay S Pitteri Sharon J SJ
Journal of proteome research 20180920 10
Triple negative breast cancer is an aggressive, heterogeneous disease with high recurrence and metastasis rates even with modern chemotherapy regimens and thus is in need of new therapeutics. Here, three novel synthetic analogues of chalcones, plant-based molecules that have demonstrated potency against a wide variety of cancers, were investigated as potential therapeutics for triple negative breast cancer. These compounds exhibit IC<sub>50</sub> values of ∼5 μM in triple negative breast cancer ...[more]