Sexual dimorphic correlation of IGFBP-2 and -3 with vitamin D status
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood
SUBMITTER: 
Antigoni Manousopoulou
LAB HEAD: Spiros D. Garbis
PROVIDER: PXD009606 | Pride | 2018-10-17
REPOSITORIES: Pride
Dataset's files
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Publications
Sex-specific correlation of IGFBP-2 and IGFBP-3 with vitamin D status in adults with obesity: a cross-sectional serum proteomics study.
Al-Daghri Nasser M NM Manousopoulou Antigoni A Alokail Majed S MS Yakout Sobhy S Alenad Amal A Garay-Baquero Diana J DJ Fotopoulos Miltiadis M Teng Jie J Al-Attas Omar O Al-Saleh Yousef Y Sabico Shaun S Chrousos George P GP Garbis Spiros D SD
Nutrition & diabetes 20181004 1
<h4>Objective</h4>Subjects with low vitamin D levels are at risk of cardiometabolic disease. The aim of this study was to identify novel serological markers linking vitamin D status with cardiometabolic profile in non-diabetic adults with obesity.<h4>Methods</h4>For the discovery phase, we used quantitative serum proteomics in sex-matched, age-matched and BMI-matched subjects with obesity [BMI: 25-35 kg/m<sup>2</sup>] and low [25(OH)D < 50 nmol/L] vs. high vitamin D status [25(OH)D > 50 nmol/L] ...[more]
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2011-08-31 | E-GEOD-24104 | biostudies-arrayexpress
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Project description:BackgroundVitamin D can influence more than 200 genes in various tissues showing its credibility among the fat-soluble vitamins. Vitamin D deficiency is directly proportional to major clinical conditions such as cardiovascular diseases, diabetes, malignancy, and multiple sclerosis. This study was conducted to determine the vitamin D level of individuals and its association with depression.MethodsVitamin D levels of 100 healthy and 100 depressed subjects were determined. The isolated subjects were screened on the Beck Depression Inventory (BDI) scale and divided into three groups according to their age. Group-I comprised subjects of age 20 years and below, Group-II included subjects of age 21 to 60, and Group-III comprised subjects of ≥ 61 years of age. A sufficient level of vitamin D in normal subjects was noted, while mild deficiency of vitamin D status was observed in depressed subjects.ResultsOur study has reported a higher percentage of vitamin D deficiency in the Peshawar region. The results of our study indicated that depression was common in individuals having vitamin D deficiency.ConclusionsThe study showed a very high frequency of vitamin D deficiency in subjects with depression in Peshawar, Pakistan. The deficiency of vitamin D was observed more in females as compared to males. Further studies should explicate whether the highly widespread vitamin D deficiency could be cost-effectively treated as part of preventive or treatment interventions for depression.
| S-EPMC9389668 | biostudies-literature