Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Kidney
SUBMITTER: Saskia Neher
LAB HEAD: Saskia B. Neher
PROVIDER: PXD009641 | Pride | 2019-11-12
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 30 |
Roberts Benjamin S BS Babilonia-Rosa Melissa A MA Broadwell Lindsey J LJ Wu Ming Jing MJ Neher Saskia B SB
The EMBO journal 20180801 19
Lipoprotein lipase (LPL) is a secreted lipase that clears triglycerides from the blood. Proper LPL folding and exit from the endoplasmic reticulum (ER) require lipase maturation factor 1 (LMF1), an ER-resident transmembrane protein, but the mechanism involved is unknown. We used proteomics to identify LMF1-binding partners necessary for LPL secretion in HEK293 cells and found these to include oxidoreductases and lectin chaperones, suggesting that LMF1 facilitates the formation of LPL's five disu ...[more]