Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): B Cell, Cell Suspension Culture
DISEASE(S): Acute Leukemia
SUBMITTER: Pankaj Dwivedi
LAB HEAD: Kenneth Greis
PROVIDER: PXD009662 | Pride | 2018-07-11
REPOSITORIES: Pride
Action | DRS | |||
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Q741XRAWDATA.zip | Other | |||
QuantpYfiles.xlsx | Xlsx | |||
SearchEngineOutput.zip | Other | |||
T618IRAWDATA.zip | Other | |||
WTRAWDATA.zip | Other |
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Leukemia 20180705 1
Granulocyte-colony stimulating factor receptor (G-CSFR) controls myeloid progenitor proliferation and differentiation to neutrophils. Mutations in CSF3R (encoding G-CSFR) have been reported in patients with chronic neutrophilic leukemia (CNL) and acute myeloid leukemia (AML); however, despite years of research, the malignant downstream signaling of the mutated G-CSFRs is not well understood. Here, we used a quantitative phospho-tyrosine analysis to generate a comprehensive signaling map of G-CSF ...[more]