Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Veerle Paternoster
LAB HEAD: Johan Palmfeldt
PROVIDER: PXD009692 | Pride | 2019-01-07
REPOSITORIES: Pride
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Paternoster Veerle V Svanborg Maria M Edhager Anders Valdemar AV Rajkumar Anto P AP Eickhardt Esben Ahlburg EA Pallesen Jonatan J Grove Jakob J Qvist Per P Fryland Tue T Wegener Gregers G Nyengaard Jens Randel JR Mors Ole O Palmfeldt Johan J Børglum Anders Dupont AD Christensen Jane Hvarregaard JH
Neurobiology of disease 20181224
Genetic and molecular studies have implicated the Bromodomain containing 1 (BRD1) gene in the pathogenesis of schizophrenia and bipolar disorder. Accordingly, mice heterozygous for a targeted deletion of Brd1 (Brd1<sup>+/-</sup> mice) show behavioral phenotypes with broad translational relevance to psychiatric disorders. BRD1 encodes a scaffold protein that affects the expression of many genes through modulation of histone acetylation. BRD1 target genes have been identified in cell lines; howeve ...[more]