Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Escherichia Coli
SUBMITTER: Kentaro Ishii
LAB HEAD: Susumu Uchiyama
PROVIDER: PXD009732 | Pride | 2018-10-18
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
WTATP.CMP | Other | |||
WTATP.DAT | Other | |||
WTATpgS.CMP | Other | |||
WTATpgS.DAT | Other | |||
dNATP.CMP | Other |
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Uchihashi Takayuki T Watanabe Yo-Hei YH Nakazaki Yosuke Y Yamasaki Takashi T Watanabe Hiroki H Maruno Takahiro T Ishii Kentaro K Uchiyama Susumu S Song Chihong C Murata Kazuyoshi K Iino Ryota R Ando Toshio T
Nature communications 20180601 1
The ATP-dependent bacterial protein disaggregation machine, ClpB belonging to the AAA+ superfamily, refolds toxic protein aggregates into the native state in cooperation with the cognate Hsp70 partner. The ring-shaped hexamers of ClpB unfold and thread its protein substrate through the central pore. However, their function-related structural dynamics has remained elusive. Here we directly visualize ClpB using high-speed atomic force microscopy (HS-AFM) to gain a mechanistic insight into its disa ...[more]