Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human) Gallus Gallus (chicken) Influenza A Virus (a/wsn/1933(h1n1))
TISSUE(S): Epithelial Cell Of Lung, Cell Culture
DISEASE(S): Influenza
SUBMITTER: Emilio Yángüez
LAB HEAD: Silke Stertz
PROVIDER: PXD009999 | Pride | 2018-09-13
REPOSITORIES: Pride
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IAVvsMock_IMAC_1.raw | Raw | |||
IAVvsMock_IMAC_2.raw | Raw | |||
IAVvsMock_IMAC_3.raw | Raw | |||
IAVvsMock_IMAC_4.raw | Raw | |||
IAVvsMock_IMAC_5.raw | Raw |
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Yángüez Emilio E Hunziker Annika A Dobay Maria Pamela MP Yildiz Soner S Schading Simon S Elshina Elizaveta E Karakus Umut U Gehrig Peter P Grossmann Jonas J Dijkman Ronald R Schmolke Mirco M Stertz Silke S
Nature communications 20180911 1
Although annual influenza epidemics affect around 10% of the global population, current treatment options are limited and development of new antivirals is needed. Here, using quantitative phosphoproteomics, we reveal the unique phosphoproteome dynamics that occur in the host cell within minutes of influenza A virus (IAV) infection. We uncover cellular kinases required for the observed signaling pattern and find that inhibition of selected candidates, such as the G protein-coupled receptor kinase ...[more]