Proteomics

Dataset Information

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Loqs2 (AAEL013721) interactome in Aedes aegypti Aag2 cells (FLAG-tag)


ABSTRACT: Loquacious-2 (Loqs2) is a recently identified paralog of Loquacious found in Aedes aegypti. Data presented here allowed the proteomic characterization of Loqs2 interactome in Aedes aegypti Aag2 cells. We carried out immunoprecipitation experiments where Loqs2 tagged protein was precipitated along with its partners. Immunoprecipitation of tagged eGFP protein was performed in the same conditions to verify the specificity of these associations. Experiments were performed in biological triplicates.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Aedes Aegypti

SUBMITTER: Lauriane Kuhn  

LAB HEAD: Elisa Andrade

PROVIDER: PXD010191 | Pride | 2018-11-21

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
2018_S11_Elisa_GFPflag1dil5.mgf Mgf
2018_S11_Elisa_GFPflag1dil5.wiff Wiff
2018_S11_Elisa_GFPflag1dil5.wiff.scan Wiff
2018_S11_Elisa_GFPflag2dil5.mgf Mgf
2018_S11_Elisa_GFPflag2dil5.wiff Wiff
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Publications


Dengue virus (DENV) is an arbovirus transmitted to humans by Aedes mosquitoes<sup>1</sup>. In the insect vector, the small interfering RNA (siRNA) pathway is an important antiviral mechanism against DENV<sup>2-5</sup>. However, it remains unclear when and where the siRNA pathway acts during the virus cycle. Here, we show that the siRNA pathway fails to efficiently silence DENV in the midgut of Aedes aegypti although it is essential to restrict systemic replication. Accumulation of DENV-derived s  ...[more]

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