Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Aedes Aegypti
SUBMITTER: Lauriane Kuhn
LAB HEAD: Elisa Andrade
PROVIDER: PXD010191 | Pride | 2018-11-21
REPOSITORIES: Pride
Items per page: 1 - 5 of 24 |
Nature microbiology 20181029 12
Dengue virus (DENV) is an arbovirus transmitted to humans by Aedes mosquitoes<sup>1</sup>. In the insect vector, the small interfering RNA (siRNA) pathway is an important antiviral mechanism against DENV<sup>2-5</sup>. However, it remains unclear when and where the siRNA pathway acts during the virus cycle. Here, we show that the siRNA pathway fails to efficiently silence DENV in the midgut of Aedes aegypti although it is essential to restrict systemic replication. Accumulation of DENV-derived s ...[more]