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Identification of glutamate receptor delta-1 interactome at synapses.

ABSTRACT: In this project, we have investigated the interactome of the glutamate receptor delta-1 (GluD1) in developing synapses in mice. GluD1 is a member of the delta subfamily of ionotropic glutamate receptors widely expressed in the brain. It behaves as a postsynaptic organizer by engaging in trans-synaptic interaction and by mediating postsynaptic signaling.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Guillaume Arras

LAB HEAD: Damarys Loew

PROVIDER: PXD010373 | Pride | 2019-11-06

REPOSITORIES: Pride

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			Action	DRS
	C5035FD.msf	Msf
	C5035FD.raw	Raw
	C5036FD.msf	Msf
	C5036FD.raw	Raw
	C5347FD.msf	Msf

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Publications

Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.

Fossati Matteo M Assendorp Nora N Gemin Olivier O Colasse Sabrina S Dingli Florent F Arras Guillaume G Loew Damarys D Charrier Cécile C

Neuron 20191105 6

Fine orchestration of excitatory and inhibitory synaptic development is required for normal brain function, and alterations may cause neurodevelopmental disorders. Using sparse molecular manipulations in intact brain circuits, we show that the glutamate receptor delta-1 (GluD1), a member of ionotropic glutamate receptors (iGluRs), is a postsynaptic organizer of inhibitory synapses in cortical pyramidal neurons. GluD1 is selectively required for the formation of inhibitory synapses and regulates ...[more]

PMID: 31704028

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