Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Stromal Cell
DISEASE(S): Chronic Lymphocytic Leukemia
SUBMITTER: James Williamson
LAB HEAD: Ingo Ringshausen
PROVIDER: PXD010401 | Pride | 2018-09-19
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
IR-MM_CLL-PMP_F-1.mzML | Mzml | |||
IR-MM_CLL-PMP_F-1.mzid.gz | Mzid | |||
IR-MM_CLL-PMP_F1.raw | Raw | |||
IR-MM_CLL-PMP_F10.raw | Raw | |||
IR-MM_CLL-PMP_F11.raw | Raw |
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Nature communications 20180921 1
The Wnt signalling pathway, one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL), is activated in only a subset of patients through somatic mutations. Here we describe alternative, microenvironment-dependent mechanisms of Wnt activation in malignant B cells. We show that tumour cells specifically induce Notch2 activity in mesenchymal stromal cells (MSCs) required for the transcription of the complement factor C1q. MSC-derived C1q in turn inhibits Gsk3-β mediated degradati ...[more]