Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: E-MTAB-6823
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Karel Harant
LAB HEAD: Jan Brábek
PROVIDER: PXD010425 | Pride | 2020-04-23
REPOSITORIES: Pride
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Čermák Vladimír V Gandalovičová Aneta A Merta Ladislav L Harant Karel K Rösel Daniel D Brábek Jan J
Scientific data 20200527 1
The plasticity of cancer cell invasion represents substantial hindrance for effective anti-metastatic therapy. To better understand the cancer cells' plasticity, we performed complex transcriptomic and proteomic profiling of HT1080 fibrosarcoma cells undergoing mesenchymal-amoeboid transition (MAT). As amoeboid migratory phenotype can fully manifest only in 3D conditions, all experiments were performed with 3D collagen-based cultures. Two previously described approaches to induce MAT were used: ...[more]