Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Vadim Demichev
LAB HEAD: Markus Ralser
PROVIDER: PXD010529 | Pride | 2018-09-13
REPOSITORIES: Pride
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KL_StMix2_020514.wiff | Wiff | |||
KL_StMix2_020514.wiff.scan | Wiff | |||
KL_StMix_1_020514.wiff | Wiff | |||
KL_StMix_1_020514.wiff.scan | Wiff | |||
KL_StMix_26b.wiff | Wiff |
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Zelezniak Aleksej A Vowinckel Jakob J Capuano Floriana F Messner Christoph B CB Demichev Vadim V Polowsky Nicole N Mülleder Michael M Kamrad Stephan S Klaus Bernd B Keller Markus A MA Ralser Markus M
Cell systems 20180905 3
A challenge in solving the genotype-to-phenotype relationship is to predict a cell's metabolome, believed to correlate poorly with gene expression. Using comparative quantitative proteomics, we found that differential protein expression in 97 Saccharomyces cerevisiae kinase deletion strains is non-redundant and dominated by abundance changes in metabolic enzymes. Associating differential enzyme expression landscapes to corresponding metabolomes using network models provided reasoning for poor pr ...[more]