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Plasma Proteome Dynamics in the Pig Model of Trauma

ABSTRACT: The effect of IV-adminstered Vitamin C on the plasma proteome in the pig trauma model was investigated with label free proteomics. Plasma samples were drawn from 9 male Sinclair swine at baseline, post-trauma, and 0.25, 2, and 4 hourspost resuscitation with 500 mL of hydroxyethyl starch. Swine were randomized to receive either saline, low-dose VitC (50 mg/kg), or high-dose VitC (200 mg/kg) during volume resuscitation (N = 3/treatment). High performance LC-MS/MS proteomics was then used to quantitatively measure plasma protein fluctations over time as a function of treatment.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

SUBMITTER: Adam Hawkridge

LAB HEAD: Adam Hawkridge

PROVIDER: PXD010608 | Pride | 2022-03-11

REPOSITORIES: pride

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			Action	DRS
	ADAMTS13Andromeda.zip	Other
	ADAMTS13MQAnalysistxt.zip	Other
	ADAMTS13MQExperimentalDesignTemplate.txt	Txt
	OriginalAndromeda.zip	Other
	OriginalMQAnalysistxt.zip	Other

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Plasma Proteome Dynamics in the Pig Model of Trauma

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