Dataset Information

Plasma Proteome Dynamics in the Pig Model of Trauma

ABSTRACT: The effect of IV-adminstered Vitamin C on the plasma proteome in the pig trauma model was investigated with label free proteomics. Plasma samples were drawn from 9 male Sinclair swine at baseline, post-trauma, and 0.25, 2, and 4 hourspost resuscitation with 500 mL of hydroxyethyl starch. Swine were randomized to receive either saline, low-dose VitC (50 mg/kg), or high-dose VitC (200 mg/kg) during volume resuscitation (N = 3/treatment). High performance LC-MS/MS proteomics was then used to quantitatively measure plasma protein fluctations over time as a function of treatment.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

SUBMITTER: Adam Hawkridge

LAB HEAD: Adam Hawkridge

PROVIDER: PXD010608 | Pride | 2022-03-11

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	ADAMTS13Andromeda.zip	Other
	ADAMTS13MQAnalysistxt.zip	Other
	ADAMTS13MQExperimentalDesignTemplate.txt	Txt
	OriginalAndromeda.zip	Other
	OriginalMQAnalysistxt.zip	Other

Items per page:

1 - 5 of 7

Publications

Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment.

Cudjoe Emmanuel K EK Hassan Zaneera H ZH Kang Le L Reynolds Penny S PS Fisher Bernard J BJ McCarter Jacquelyn J Sweeney Christopher C Martin Erika J EJ Middleton Paul P Ellenberg Matthew M Fowler Alpha A AA Spiess Bruce D BD Brophy Donald F DF Hawkridge Adam M AM Natarajan Ramesh R

Journal of thrombosis and haemostasis : JTH 20190825 11

<h4>Background</h4>Fluid resuscitation plays a prominent role in stabilizing trauma patients with hemorrhagic shock yet there remains uncertainty with regard to optimal administration time, volume, and fluid composition (e.g., whole blood, component, colloids) leading to complications such as trauma-induced coagulopathies (TIC), acidosis, and poor oxygen transport. Synthetic fluids in combination with antioxidants (e.g., vitamin C) may resolve some of these problems.<h4>Objectives</h4>We applied ...[more]

PMID: 31322812

Dataset Information

Plasma Proteome Dynamics in the Pig Model of Trauma

Dataset's files

Publications

Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Similar Datasets

Plasma Proteome Dynamics in the Pig Model of Trauma
2019-07-29 | PXD012454 | Pride

Extracellular microRNA: Novel Biomarker and Potential Therapeutic Target in Trauma
2023-03-22 | GSE223151 | GEO

IL-6-mediated activation of STAT3M-NM-1 prevents trauma/hemorrhagic shock-induced liver inflammation
2011-03-16 | E-GEOD-27978 | biostudies-arrayexpress

Nanostring human miRNA panel: exosome fraction from peripheral blood of trauma patients versus healthy
2024-04-03 | GSE243485 | GEO

2021 Trauma plasma H14 depleted proteomics
2021-02-23 | MSV000086942 | MassIVE

Transcriptomic response of murine liver to severe injury and hemorrhagic shock: Affymetrix portion of dual platform
2011-01-24 | E-GEOD-26695 | biostudies-arrayexpress

Transcriptomic response of murine liver to severe injury and hemorrhagic shock: CodeLink portion of dual platform
2011-01-24 | E-GEOD-26696 | biostudies-arrayexpress

Transcriptomic profiling of S2/S3 proximal tubules in response to LPS treatment
2018-10-06 | GSE120879 | GEO

Collagen induced arthritis plasma proteomic analysis
2020-09-18 | PXD015274 | Pride