Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Retinal Pigment Epithelial Cell, Cell Culture
SUBMITTER: Kerrie McNally
LAB HEAD: Peter J Cullen
PROVIDER: PXD010632 | Pride | 2018-10-16
REPOSITORIES: Pride
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Nature communications 20180913 1
Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-retromer assembly for Wntless transport and report that SNX3 associates with an evolutionary conserved endosome-associated membrane re-modelling complex composed of MON2, DOPEY2 and the putative aminopho ...[more]