Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Sus Scrofa (pig)
TISSUE(S): Cell Culture
SUBMITTER: xiaomei li
LAB HEAD: guiqing peng
PROVIDER: PXD010685 | Pride | 2020-05-26
REPOSITORIES: Pride
Dong Wanyu W Xie Wenting W Liu Yunbo Y Sui Baokun B Zhang Hao H Liu Liran L Tan Yubei Y Tong Xiaohan X Fu Zhen F ZF Yin Ping P Fang Liurong L Peng Guiqing G
Antiviral research 20191118
Emerging coronaviruses (CoVs) primarily cause severe gastroenteric or respiratory diseases in humans and animals, and no approved therapeutics are currently available. Here, A9, a receptor tyrosine kinase inhibitor (RTKI) of the tyrphostin class, is identified as a robust inhibitor of transmissible gastroenteritis virus (TGEV) infection in cell-based assays. Moreover, A9 exhibited potent antiviral activity against the replication of various CoVs, including murine hepatitis virus (MHV), porcine e ...[more]