Proteomics

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Molecular profiling of innate immune response mechanisms in ventilator associated pneumonia (VAP)

ABSTRACT: Ventilator associated pneumonia (VAP) is the 2nd most common hospital acquired infection associated with high morbidity, mortality and increased hospitalization. Current practice of diagnosis is based on clinical symptoms and bronchoalvolar lavage (BAL) culture. The procedures of BAL collections are invasive whereas, endotracheal aspirate (ETA), a matrix of upper airway collection is minimally invasive and underexplored in VAP diagnosis. The study describes first in detail characterization of proteome of longitudinal ETA collections from 16 intubated patients including 11 VAP patients and explores potential utility of ETA in VAP diagnosis.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Bronchoalveolar Lavage

DISEASE(S): Pneumonia

SUBMITTER: Krystine Mansfield  

LAB HEAD: Patrick Pirrotte

PROVIDER: PXD010715 | Pride | 2020-07-27

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
040_0001_000_Percolator_Multiconsensus_P26_1_3_5_7_B1_Proteins-1.pdResult Other
040_0001_01F_11x1_Percolator_multiconsensus.pdResult Other
040_0001_01F_C_10x1_13SEP16_ETA_HUM_LUM_0002_PA_95MIN_MS_KP_01.raw Raw
040_0001_01F_C_10x1_13SEP16_ETA_HUM_LUM_0002_PA_95MIN_MS_KP_012.msf Msf
040_0001_01F_C_10x2_06SEP16_ETA_HUM_LUM_0002_PA_95MIN_MS_KP_01.msf Msf
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Publications

Molecular Profiling of Innate Immune Response Mechanisms in Ventilator-associated Pneumonia.

Pathak Khyatiben V KV   McGilvrey Marissa I MI   Hu Charles K CK   Garcia-Mansfield Krystine K   Lewandoski Karen K   Eftekhari Zahra Z   Yuan Yate-Ching YC   Zenhausern Frederic F   Menashi Emmanuel E   Pirrotte Patrick P  

Molecular & cellular proteomics : MCP 20200724 10

Ventilator-associated pneumonia (VAP) is a common hospital-acquired infection, leading to high morbidity and mortality. Currently, bronchoalveolar lavage (BAL) is used in hospitals for VAP diagnosis and guiding treatment options. Although BAL collection procedures are invasive, alternatives such as endotracheal aspirates (ETA) may be of diagnostic value, however, their use has not been thoroughly explored. Longitudinal ETA and BAL were collected from 16 intubated patients up to 15 days, of which  ...[more]

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