Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human) Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Sl1344 Mus Musculus (mouse)
TISSUE(S): Macrophage
SUBMITTER: Nichollas Scott
LAB HEAD: Elizabeth L Hartland
PROVIDER: PXD010769 | Pride | 2019-03-27
REPOSITORIES: Pride
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Molecular & cellular proteomics : MCP 20190322 6
Strains of <i>Salmonella</i> utilize two distinct type three secretion systems to deliver effector proteins directly into host cells. The <i>Salmonella</i> effectors SseK1 and SseK3 are arginine glycosyltransferases that modify mammalian death domain containing proteins with <i>N</i>-acetyl glucosamine (GlcNAc) when overexpressed ectopically or as recombinant protein fusions. Here, we combined Arg-GlcNAc glycopeptide immunoprecipitation and mass spectrometry to identify host proteins GlcNAcylate ...[more]