Ontology highlight
ABSTRACT:
INSTRUMENT(S): maXis
ORGANISM(S): Homo Sapiens (human) Sus Scrofa Domesticus (domestic Pig)
TISSUE(S): Heart, Kidney
SUBMITTER: kyle brown
LAB HEAD: Ying Ge
PROVIDER: PXD010825 | Pride | 2019-03-29
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Azo-CardiacTissue-SRandMit-2.baf | Other | |||
Azo-CardiacTissue-SRandMit.OUTPUT_TABLE | Other | |||
Azo-CardiacTissue-SRandMit.baf | Other | |||
Azo-CardiacTissue-SRandMit.msalign | Other | |||
Azo-CardiacTissue-SRandMit_2.OUTPUT_TABLE | Other |
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Brown Kyle A KA Chen Bifan B Guardado-Alvarez Tania M TM Lin Ziqing Z Hwang Leekyoung L Ayaz-Guner Serife S Jin Song S Ge Ying Y
Nature methods 20190415 5
We report the identification of a photocleavable anionic surfactant, 4-hexylphenylazosulfonate (Azo), which can be rapidly degraded by ultraviolet irradiation, for top-down proteomics. Azo can effectively solubilize proteins with performance comparable to that of sodium dodecyl sulfate (SDS) and is compatible with mass spectrometry. Azo-aided top-down proteomics enables the solubilization of membrane proteins for comprehensive characterization of post-translational modifications. Moreover, Azo i ...[more]