Proteomics

Dataset Information

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HEK293 Ku70 WT BioID - Mapping the Ku interactome using proximity-dependent biotin identification in human cells


ABSTRACT: We conducted proximity-dependent biotin identification (BioID) using wild-type Ku70 in HEK293 cells. Ku70 is part of a protein complex known as Ku, which is involved in a variety of functions throughout the cell. By identifying candidate protein interactors, we can infer new cellular processes that may involve the Ku complex.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Sanna Abbasi  

LAB HEAD: Caroline Schild-Poulter

PROVIDER: PXD010931 | Pride | 2019-01-03

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
HEK293_Control.mzid.gz Mzid
HEK293_Control.pride.mztab.gz Mztab
HEK293_Control.raw Raw
Ku70_BioID_Rep_1.mzid.gz Mzid
Ku70_BioID_Rep_1.pride.mztab.gz Mztab
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Publications

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

Abbasi Sanna S   Schild-Poulter Caroline C  

Journal of proteome research 20190114 3


The Ku heterodimer, composed of Ku70 and Ku80, is best characterized for its role in repairing double-stranded DNA breaks but is also known to participate in other regulatory processes. Despite our understanding of Ku protein interplay during DNA repair, the extent of Ku's protein interactions in other processes has never been fully determined. Using proximity-dependent biotin identification (BioID) and affinity purification coupled to mass spectrometry (AP-MS) with wild-type Ku70, we identified  ...[more]

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