Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Embryonic Stem Cell
SUBMITTER: Jeroen Demmers
LAB HEAD: Jeroen Demmers
PROVIDER: PXD010944 | Pride | 2018-11-15
REPOSITORIES: Pride
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Gontan Cristina C Mira-Bontenbal Hegias H Magaraki Aristea A Dupont Catherine C Barakat Tahsin Stefan TS Rentmeester Eveline E Demmers Jeroen J Gribnau Joost J
Nature communications 20181112 1
In mice, imprinted X chromosome inactivation (iXCI) of the paternal X in the pre-implantation embryo and extraembryonic tissues is followed by X reactivation in the inner cell mass (ICM) of the blastocyst to facilitate initiation of random XCI (rXCI) in all embryonic tissues. RNF12 is an E3 ubiquitin ligase that plays a key role in XCI. RNF12 targets pluripotency protein REX1 for degradation to initiate rXCI in embryonic stem cells (ESCs) and loss of the maternal copy of Rnf12 leads to embryonic ...[more]