Dataset Information

Hypoxia-induced changes in SUMO conjugation affect transcriptional regulation under low oxygen

ABSTRACT: Recent data support that sumoylation, the covalent attachment of the Small Ubiquitin-related MOdifier (SUMO) to proteins, is involved in the activation of the hypoxic response and the ensuing signalling cascade. To gain insights into differences of the SUMO1 and SUMO2/3 proteome of HeLa cells under normoxia and cells grown for 48 h under hypoxic conditions, we employed endogenous SUMO-immunoprecipitation in combination with quantitative mass spectrometry (SILAC).

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hela Cell

SUBMITTER: Kuan-Ting Pan

LAB HEAD: Henning Urlaub

PROVIDER: PXD010946 | Pride | 2019-04-03

REPOSITORIES: Pride

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			Action	DRS
	G_Chachami_200813_020913_L2_18.RAW	Raw
	G_Chachami_200813_020913_L2_19.RAW	Raw
	G_Chachami_200813_020913_L2_20.RAW	Raw
	G_Chachami_200813_020913_L2_21.RAW	Raw
	G_Chachami_200813_020913_L2_22.RAW	Raw

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Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.

Chachami Georgia G Stankovic-Valentin Nicolas N Karagiota Angeliki A Basagianni Angeliki A Plessmann Uwe U Urlaub Henning H Melchior Frauke F Simos George G

Molecular & cellular proteomics : MCP 20190329 6

Hypoxia occurs in pathological conditions, such as cancer, as a result of the imbalance between oxygen supply and consumption by proliferating cells. HIFs are critical molecular mediators of the physiological response to hypoxia but also regulate multiple steps of carcinogenesis including tumor progression and metastasis. Recent data support that sumoylation, the covalent attachment of the Small Ubiquitin-related MOdifier (SUMO) to proteins, is involved in the activation of the hypoxic response ...[more]

PMID: 30926672

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