Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Prostate Gland, Cell Culture
DISEASE(S): Prostate Adenocarcinoma
SUBMITTER: Ignacio Ortea
LAB HEAD: Ignacio Ortea
PROVIDER: PXD010993 | Pride | 2019-01-14
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
2015018-all4samples.group | Other | |||
20150724-06_2015018-A.wiff | Wiff | |||
20150724-06_2015018-A.wiff.scan | Wiff | |||
20150724-07_2015018-B.wiff | Wiff | |||
20150724-07_2015018-B.wiff.scan | Wiff |
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Journal of proteomics 20181025
Galiellalactone (GL) is a fungal metabolite that presents antitumor and antiinflammatory activities in vitro and in vivo. Previous studies have shown that GL targets NF-κB and STAT3 pathways and induces G<sub>2</sub>/M cell cycle arrest in androgen-insensitive prostate cancer cells. In this study, we show that GL-induced cell cycle arrest is independent of the NF-κB and STAT3 pathways in DU145 and PC-3 cells, and also that GL did not affect cell cycling in androgen-sensitive prostate cancer cell ...[more]