Proteomics

Dataset Information

0

Proteome profiling in APP/PS1 mice brain and modulation by tocotrienol-rich fraction

ABSTRACT: This study examined the proteome profile in the hippocampus, medial prefrontal cortex, and striatum of APPswe/PS1dE9 transgenic mice (APP/PS1) model of Alzheimer’s disease compared to wild-type mice. The effect of tocotrienol-rich fraction (TRF), a mixture of vitamin E analogs derived from palm oil supplementation on the proteome profile of APP/PS1 mice hippocampus, medial prefrontal cortex, and striatum was also investigated. The analysis was performed using ultrahigh-performance liquid chromatography coupled with Q Exactive HF Orbitrap mass spectrometry. This study was in hoped to understand the mechanisms of Alzheimer’s disease at proteome level, and pre-emptive activity of TRF to combat the disease.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Hamizah Shahirah Hamezah  

LAB HEAD: Ikuo Tooyama

PROVIDER: PXD011068 | Pride | 2019-12-06

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
Hippocampus_Andromeda.zip Other
Hippocampus_MaxQuant.zip Other
PO1-HP1.raw Raw
PO1-HP2.raw Raw
PO1-HP3.raw Raw
Items per page:
1 - 5 of 222
altmetric image

Publications

Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.

Hamezah Hamizah Shahirah HS   Durani Lina Wati LW   Yanagisawa Daijiro D   Ibrahim Nor Faeizah NF   Aizat Wan Mohd WM   Makpol Suzana S   Wan Ngah Wan Zurinah WZ   Damanhuri Hanafi Ahmad HA   Tooyama Ikuo I  

Journal of Alzheimer's disease : JAD 20190101 1

Tocotrienol-rich fraction (TRF) is a mixture of vitamin E analogs derived from palm oil. We previously demonstrated that supplementation with TRF improved cognitive function and modulated amyloid pathology in AβPP/PS1 mice brains. The current study was designed to examine proteomic profiles underlying the therapeutic effect of TRF in the brain. Proteomic analyses were performed on samples of hippocampus, medial prefrontal cortex (mPFC), and striatum using liquid chromatography coupled to Q Exact  ...[more]

Similar Datasets

Transcriptomics RNA-seq of mouse brain tissue investigating the effect of absence of microglia in a mouse model of ß-amyloidopathy
2024-10-15 | E-MTAB-14231 | biostudies-arrayexpress
Proteomics Proteome profiling in aging rat brain by LC-MS/MS
2018-07-12 | PXD009212 | Pride
Transcriptomics Single-cell sequencing of FACS-sorted mouse astrocytes, investigating the effect of absence of microglia in a mouse model of ß-amyloidopathy
2024-10-15 | E-MTAB-14233 | biostudies-arrayexpress
Transcriptomics RNA-seq of hippocampal samples from IL-18KO/APP/PS1 , WT, IL-18KO, and APP/PS1 mice.
2017-12-31 | E-MTAB-5668 | biostudies-arrayexpress
Transcriptomics Innovations in primate interneuron repertoire
2020-06-04 | GSE151761 | GEO
Transcriptomics Striatum transcriptome analysis of Shank3 knock-out/heterozygous mice
2019-09-11 | GSE124946 | GEO
Transcriptomics Brain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder
2015-04-20 | E-GEOD-45035 | biostudies-arrayexpress
Transcriptomics Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model (RNA-Seq)
2020-07-09 | GSE145907 | GEO
Genomics Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model (ATAC-Seq)
2020-07-09 | GSE145906 | GEO
Transcriptomics Brain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder
2015-04-20 | GSE45035 | GEO