Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Joseph Robertson
LAB HEAD: Jorrit Enserink
PROVIDER: PXD011084 | Pride | 2018-10-19
REPOSITORIES: Pride
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Herrera Maria C MC Chymkowitch Pierre P Robertson Joseph M JM Eriksson Jens J Bøe Stig Ove SO Alseth Ingrun I Enserink Jorrit M JM
Nucleic acids research 20181201 22
tRNA genes are transcribed by RNA polymerase III (RNAPIII). During recent years it has become clear that RNAPIII activity is strictly regulated by the cell in response to environmental cues and the homeostatic status of the cell. However, the molecular mechanisms that control RNAPIII activity to regulate the amplitude of tDNA transcription in normally cycling cells are not well understood. Here, we show that tRNA levels fluctuate during the cell cycle and reveal an underlying molecular mechanism ...[more]