Sequential modulation of RNase III and RNase G expression in response to host environment conditions promotes pathogenicity through the control of hns expression in Salmonella Typhimurium
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ABSTRACT: Our results demonstrate that RNase G controls expression levels of H-NS encoded by hns, strongly associated with the pathogenicity of S. Typhimurium. The hns mRNA abundance is mediated by RNase G, which cleaves the 5’-UTR of hns mRNA. In the upstream pathway, the induced expression of RNase G in host environment condition is attributable to reduced RNase III cleavage activity on rng mRNA. Our findings suggest the link between Salmonella pathogenicity and RNase III-RNase G pathway, underlining the importance of posttranscriptional regulation of H-NS in the downstream pathway, which controls Salmonella pathogenicity island-1 type III secretion system for the survival and virulence of S. Typhimurium in host cell.
INSTRUMENT(S): ProteomeDiscoverer input parameter
ORGANISM(S): Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Sl1344
TISSUE(S): Cell Line Cell
DISEASE(S): Salmonellosis
SUBMITTER: Yong-Hak Kim
LAB HEAD: Yong-Hak Kim
PROVIDER: PXD011090 | Pride | 2021-01-08
REPOSITORIES: Pride
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