Proteomics

Dataset Information

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Mouse Nedd4-2 and control with Pirfenidone


ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 in lung epithelial cells in adult mice produces chronic lung disease that shares key features with IPF including progressive fibrosis and bronchiolization with increased expression of Muc5b in peripheral airways, honeycombing and characteristic alterations in the lung proteome.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

SUBMITTER: Alexander Held  

LAB HEAD: Ursula Klingmüller

PROVIDER: PXD011119 | Pride | 2020-03-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MaxQuant_Output.zip Other
qepls_180727_19-021_MS_PZ_10_F7-7_19.raw Raw
qepls_180727_19-021_MS_PZ_12_F7-7_28.raw Raw
qepls_180727_19-021_MS_PZ_14_F7-7_2.raw Raw
qepls_180727_19-021_MS_PZ_16_F7-7_11.raw Raw
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Publications


Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 (Nedd4l) in lung epithelial cells in adult mice produces chronic lung disease sharing key features with IPF including progressive fibrosis and bronchiolization with increased expression of Muc5b in peripheral airways, honeycombing and c  ...[more]

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