Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Qian Liu
LAB HEAD: Hu Zhou
PROVIDER: PXD011134 | Pride | 2019-11-12
REPOSITORIES: Pride
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Wang Kuifeng K Fang Shanhua S Liu Qian Q Gao Jing J Wang Xiaoning X Zhu Hongwen H Zhu Zhenyun Z Ji Feihong F Wu Jiasheng J Ma Yueming Y Hu Lihong L Shen Xu X Gao Daming D Zhu Jiansheng J Liu Ping P Zhou Hu H
EBioMedicine 20190327
<h4>Background</h4>Hepatic stellate cell (HSC) activation induced by transforming growth factor β1 (TGF-β1) plays a pivotal role in fibrogenesis, while the complex downstream mediators of TGF-β1 in such process are largely unknown.<h4>Methods</h4>We performed pharmacoproteomic profiling of the mice liver tissues from control, carbon tetrachloride (CCl<sub>4</sub>)-induced fibrosis and NPLC0393 administrated groups. The target gene MAT2A was overexpressed or knocked down in vivo by tail vein inje ...[more]