Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Fibroblast
SUBMITTER: Lauriane Kuhn
LAB HEAD: Régine Janel
PROVIDER: PXD011156 | Pride | 2020-02-04
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
2016_S51_RJanel_1a_5sur100_bis.mgf | Mgf | |||
2016_S51_RJanel_1a_5sur100_bis.raw | Raw | |||
2016_S51_RJanel_1b_5sur100.mgf | Mgf | |||
2016_S51_RJanel_1b_5sur100.raw | Raw | |||
2016_S51_RJanel_1c_5sur100.mgf | Mgf |
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Proteomics 20200213 3-4
It is established that short inverted repeats trigger base substitution mutagenesis in human cells. However, how the replication machinery deals with structured DNA is unknown. It has been previously reported that in human cell-free extracts, DNA primer extension using a structured single-stranded template is transiently blocked at DNA hairpins. Here, the proteomic analysis of proteins bound to the DNA template is reported and evidence that the DNA-PK complex (DNA-PKcs and the Ku heterodimer) re ...[more]