Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Ovarian Follicle, Ovary
SUBMITTER: Richard Imre
LAB HEAD: Julius Fabian Brennecke
PROVIDER: PXD011201 | Pride | 2019-06-12
REPOSITORIES: Pride
Items per page: 1 - 5 of 16 |
Nature structural & molecular biology 20190805 8
The PIWI-interacting RNA (piRNA) pathway protects genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA-guided targeting of nuclear PIWI proteins to nascent transposon transcripts, yet the subsequent molecular events are not understood. Here, we identify SFiNX (silencing factor interacting nuclear export variant), an interdependent protein complex required for Piwi-mediated cotranscriptional silencing in Drosophila. SFiNX consists o ...[more]