Proteomics

Dataset Information

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Analysis of plasmid induce proteome changes in UPAB1 under different conditions

ABSTRACT: LFQ analysis of Whole cell lysates and secreted preparation of acinetobacter baumannii UPAB1 with and without pAB5 and under different conditions

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Acinetobacter Baumannii

SUBMITTER: Nichollas Scott  

LAB HEAD: Mario Feldman

PROVIDER: PXD011341 | Pride | 2019-05-20

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Nsco_20180316_MF_P3_B1_Shaking.raw Raw
Nsco_20180316_MF_P3_B1_Static.raw Raw
Nsco_20180316_MF_P3_B1_Static_reinject.raw Raw
Nsco_20180316_MF_P3_B2_Shaking.raw Raw
Nsco_20180316_MF_P3_B2_Static.raw Raw
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Publications

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes.

Di Venanzio Gisela G   Flores-Mireles Ana L AL   Calix Juan J JJ   Haurat M Florencia MF   Scott Nichollas E NE   Palmer Lauren D LD   Potter Robert F RF   Hibbing Michael E ME   Friedman Laura L   Wang Bin B   Dantas Gautam G   Skaar Eric P EP   Hultgren Scott J SJ   Feldman Mario F MF  

Nature communications 20190624 1

Multidrug resistant (MDR) Acinetobacter baumannii poses a growing threat to global health. Research on Acinetobacter pathogenesis has primarily focused on pneumonia and bloodstream infections, even though one in five A. baumannii strains are isolated from urinary sites. In this study, we highlight the role of A. baumannii as a uropathogen. We develop the first A. baumannii catheter-associated urinary tract infection (CAUTI) murine model using UPAB1, a recent MDR urinary isolate. UPAB1 carries th  ...[more]

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