Proteomics

Dataset Information

0

Ileum and colon goblet cell proteome


ABSTRACT: This study is a comparative proteomics study of FACS sorted Muc2 expressing and non expressing cells in mouse ileum and colon.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Goblet Cell, Epithelial Cell, Colon, Ileum

SUBMITTER: Liisa Arike  

LAB HEAD: Liisa Arike

PROVIDER: PXD011527 | Pride | 2021-04-19

REPOSITORIES: Pride

Dataset's files

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Publications

Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer.

Sharpen Jack D A JDA   Dolan Brendan B   Nyström Elisabeth E L EEL   Birchenough George M H GMH   Arike Liisa L   Martinez-Abad Beatriz B   Johansson Malin E V MEV   Hansson Gunnar C GC   Recktenwald Christian V CV  

Nature communications 20220111 1


The colonic mucus layer is organized as a two-layered system providing a physical barrier against pathogens and simultaneously harboring the commensal flora. The factors contributing to the organization of this gel network are not well understood. In this study, the impact of transglutaminase activity on this architecture was analyzed. Here, we show that transglutaminase TGM3 is the major transglutaminase-isoform expressed and synthesized in the colon. Furthermore, intrinsic extracellular transg  ...[more]

Publication: 1/2

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