Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Goblet Cell, Epithelial Cell, Colon, Ileum
SUBMITTER: Liisa Arike
LAB HEAD: Liisa Arike
PROVIDER: PXD011527 | Pride | 2021-04-19
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 150 |
Sharpen Jack D A JDA Dolan Brendan B Nyström Elisabeth E L EEL Birchenough George M H GMH Arike Liisa L Martinez-Abad Beatriz B Johansson Malin E V MEV Hansson Gunnar C GC Recktenwald Christian V CV
Nature communications 20220111 1
The colonic mucus layer is organized as a two-layered system providing a physical barrier against pathogens and simultaneously harboring the commensal flora. The factors contributing to the organization of this gel network are not well understood. In this study, the impact of transglutaminase activity on this architecture was analyzed. Here, we show that transglutaminase TGM3 is the major transglutaminase-isoform expressed and synthesized in the colon. Furthermore, intrinsic extracellular transg ...[more]