Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Hela Cell
DISEASE(S): Cervix Carcinoma
SUBMITTER: Roberto Giambruno
LAB HEAD: Tiziana Bonaldi
PROVIDER: PXD011617 | Pride | 2019-10-23
REPOSITORIES: Pride
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Nucleic acids research 20200101 1
MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Microprocessor and its associated proteins. Through high resolution mass spectrometry (MS)- proteomics we discovered that this complex is extensively methylated, with 84 methylated sites associated to 19 out of its 24 subunits. The majority of the modifications occurs on arginine (R) residues (61), leading to 81 methylation events, while 30 lysine (K)-methylation events occurs on ...[more]