Proteomics

Dataset Information

0

The circadian clock components BMAL1 and Rev-Erb regulate flavivirus replication


ABSTRACT: detection and qunatitation of proteins by mass spectromerty to see the effect of drug treatment in human cell lines.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Cell Culture

SUBMITTER: Abhinav Kumar  

LAB HEAD: Prof. Nicole Zitzmann

PROVIDER: PXD011721 | Pride | 2019-11-12

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
50cm-26062018_CA04.mgf Mgf
50cm-26062018_CA04.raw Raw
50cm-26062018_CA06.mgf Mgf
50cm-26062018_CA06.raw Raw
50cm-26062018_CA09.mgf Mgf
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Publications


The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα influence several steps in the hepatitis C virus (HCV) life cycle, including particle entry into hepatocytes and RNA genome replication. Genetic knock out of Bmal1 and over-expression or activation of REV-ERB with synthetic agonists inhibits the replication of HCV and the  ...[more]

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