Proteomics

Dataset Information

0

Proteomic And Phosphoproteomic Study Of Placenta And Fetal Liver In Mice With Diet-Induced Obesity

ABSTRACT: Maternal obesity in mice negatively affects placental functionand maternal and fetal liver function. We performed a global proteomic analysis using a liquid-chromatography/mass-spectrometry system to investigate total and phosphorylated proteins in the placenta and fetal liver in a mouse model that combines maternal obesity with maternal androgen excess to identify changes in molecular pathways that might promote diseases in adulthood.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Placenta, Liver

DISEASE(S): Obesity

SUBMITTER: Egor Vorontsov  

LAB HEAD: Elisabet Stener-Victorin

PROVIDER: PXD011722 | Pride | 2019-01-24

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
2360TMTLabelingSchemeTotalandPhospho.pdf Pdf
2360_Liver-SET7_TMT_Phospho-HCD_0mc_Percolator_160913.msf Msf
2360_Liver-SET8_TMT_Phospho-HCD_0mc_Percolator_160913.msf Msf
2360_Placenta-SET5_TMT_Phospho-HCD_0mc_Percolator_160913.msf Msf
2360_Placenta-SET6_TMT_Phospho-HCD_0mc_Percolator_160913.msf Msf
Items per page:
1 - 5 of 97
altmetric image

Publications

Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver.

Fornes Romina R   Manti Maria M   Qi Xiaojuan X   Vorontsov Egor E   Sihlbom Carina C   Nyström Jenny J   Jerlhag Elisabet E   Maliqueo Manuel M   Hirschberg Angelica Lindén AL   Carlström Mattias M   Benrick Anna A   Stener-Victorin Elisabet E  

International journal of obesity (2005) 20190122 11

<h4>Background/objectives</h4>Maternal obesity together with androgen excess in mice negatively affects placental function and maternal and fetal liver function as demonstrated by increased triglyceride content with dysfunctional expression of enzymes and transcription factors involved in de novo lipogenesis and fat storage. To identify changes in molecular pathways that might promote diseases in adulthood, we performed a global proteomic analysis using a liquid-chromatography/mass-spectrometry  ...[more]

Similar Datasets

Proteomics Analysis of tetraspanin distribution on plasma and serum extracellular vesicles indicates that separate subpopulations carries CD9, CD63 and CD81
2022-05-20 | PXD026863 | Pride
Proteomics Silencing of STE20-Type Kinase STK25 in Human Aortic Endothelial and Smooth Muscle Cells is Atheroprotective
2022-05-20 | PXD031763 | Pride
Proteomics ATR inhibition enables complete tumour regression in ALK-driven NB mouse models
2021-11-02 | PXD027187 | Pride
Proteomics Proteomic changes in adipose tissue and skeletal muscle in women with PCOS
2024-01-09 | PXD025358 | Pride
Proteomics TMT-based proteome analysis of three Saccharomyces cerevisiae strains with different protein productivity
2020-10-27 | PXD018116 | Pride
Proteomics Global protein expression profiles of laboratory isolated mutants of E. coli K12, MG1655
2019-07-29 | PXD007647 | Pride
Proteomics Quantitative proteomics identifies proteins enriched in large and small extracellular vesicles
2022-10-13 | PXD029212 | Pride
Proteomics Explorative study of stimulated saliva proteome in head and neck cancer patients pre-and post-treatment
2024-10-14 | PXD047500 | Pride
Proteomics Late age- and dose-related effects on the proteome of thyroid tissue in rats after 131I exposure
2024-05-23 | PXD024786 | Pride
Proteomics Heat inactivation of foetal bovine serum performed after EV-depletion influences the proteome of cell-derived extracellular vesicles
2024-01-26 | PXD047505 | Pride