Proteomics

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Proteomic And Phosphoproteomic Study Of Placenta And Fetal Liver In Mice With Diet-Induced Obesity

ABSTRACT: Maternal obesity in mice negatively affects placental functionand maternal and fetal liver function. We performed a global proteomic analysis using a liquid-chromatography/mass-spectrometry system to investigate total and phosphorylated proteins in the placenta and fetal liver in a mouse model that combines maternal obesity with maternal androgen excess to identify changes in molecular pathways that might promote diseases in adulthood.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Placenta, Liver

DISEASE(S): Obesity

SUBMITTER: Egor Vorontsov  

LAB HEAD: Elisabet Stener-Victorin

PROVIDER: PXD011722 | Pride | 2019-01-24

REPOSITORIES: pride

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Dataset's files

Source:
Action DRS
2360TMTLabelingSchemeTotalandPhospho.pdf Pdf
2360_Liver-SET7_TMT_Phospho-HCD_0mc_Percolator_160913.msf Msf
2360_Liver-SET8_TMT_Phospho-HCD_0mc_Percolator_160913.msf Msf
2360_Placenta-SET5_TMT_Phospho-HCD_0mc_Percolator_160913.msf Msf
2360_Placenta-SET6_TMT_Phospho-HCD_0mc_Percolator_160913.msf Msf
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Publications

Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver.

Fornes Romina R   Manti Maria M   Qi Xiaojuan X   Vorontsov Egor E   Sihlbom Carina C   Nyström Jenny J   Jerlhag Elisabet E   Maliqueo Manuel M   Hirschberg Angelica Lindén AL   Carlström Mattias M   Benrick Anna A   Stener-Victorin Elisabet E  

International journal of obesity (2005) 20190122 11

<h4>Background/objectives</h4>Maternal obesity together with androgen excess in mice negatively affects placental function and maternal and fetal liver function as demonstrated by increased triglyceride content with dysfunctional expression of enzymes and transcription factors involved in de novo lipogenesis and fat storage. To identify changes in molecular pathways that might promote diseases in adulthood, we performed a global proteomic analysis using a liquid-chromatography/mass-spectrometry  ...[more]

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