Proteomics

Dataset Information

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Small cell lung cancer cell line panel whole proteome analysis

ABSTRACT: We conducted a whole proteome analysis of a panel of human small cell lung cancer cell lines that were either sensitive, moderately sensitive, or insensitive to SQLE inhibition to try and identify proteome signatures of sensititivy

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung Neuroendocrine Cell, Cell Culture

DISEASE(S): Small Cell Carcinoma

SUBMITTER: Sebastian Hayes  

LAB HEAD: Sebastian Hayes

PROVIDER: PXD011896 | Pride | 2019-01-09

REPOSITORIES: Pride

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OF0000626_TMT1.raw Raw
OF0000627_TMT1.raw Raw
OF0000628_TMT1.raw Raw
OF0000629_TMT1.raw Raw
OF0000630_TMT1.raw Raw
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Publications

Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the cholesterol biosynthetic pathway enzyme squalene epoxidase (SQLE). Using a variety of orthogonal approaches, we demonstrate that sensitivity to SQLE inhibition results not from cholestero  ...[more]

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