Dataset Information
Human pancreatic endocrine cells, LC-MS3
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Pancreatic Endocrine Cell
DISEASE(S): Diabetes Mellitus
SUBMITTER: 
Heidrun Vethe
LAB HEAD: Pedro L. Herrera
PROVIDER: PXD011933 | Pride | 2019-02-15
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 283412_m12592_HV_SDS.mzIdentML | Mzid | |||
| 283413_m12593_HV_SDS.mzIdentML | Mzid | |||
| 283414_m12594_HV_SDS.mzIdentML | Mzid | |||
| 283415_m12595_HV_SDS.mzIdentML | Mzid | |||
| 283416_m12596_HV_SDS.mzIdentML | Mzid |
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Publications
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.
Nature 20190213 7746
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insulin-expressing cells after the ablation of insulin-secreting β-cells, thus promoting diabetes recovery. Whether human islets also display this plasticity, especially in diabetic cond ...[more]
