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Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicityc

ABSTRACT: Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicityc

INSTRUMENT(S): LTQ Orbitrap, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Jody Vykoukal

LAB HEAD: Samir Hanash, MD, PhD

PROVIDER: PXD011957 | Pride | 2019-01-21

REPOSITORIES: Pride

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			Action	DRS
	IP0360_Media.txt	Txt
	IP0360_Nuclear.txt	Txt
	IP0360_Surface.txt	Txt
	IP0360_TCE.txt	Txt
	IP0361_Media.txt	Txt

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Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity.

Capello Michela M Vykoukal Jody V JV Katayama Hiroyuki H Bantis Leonidas E LE Wang Hong H Kundnani Deepali L DL Aguilar-Bonavides Clemente C Aguilar Mitzi M Tripathi Satyendra C SC Dhillon Dilsher S DS Momin Amin A AA Peters Haley H Katz Matthew H MH Alvarez Hector H Bernard Vincent V Ferri-Borgogno Sammy S Brand Randall R Adler Douglas G DG Firpo Matthew A MA Mulvihill Sean J SJ Molldrem Jeffrey J JJ Feng Ziding Z Taguchi Ayumu A Maitra Anirban A Hanash Samir M SM

Nature communications 20190116 1

Although B cell response is frequently found in cancer, there is little evidence that it alters tumor development or progression. The process through which tumor-associated antigens trigger humoral response is not well delineated. We investigate the repertoire of antigens associated with humoral immune response in pancreatic ductal adenocarcinoma (PDAC) using in-depth proteomic profiling of immunoglobulin-bound proteins from PDAC patient plasmas and identify tumor antigens that induce antibody r ...[more]

PMID: 30651550

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