IP pTKL - Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Blood
SUBMITTER: 
Chiara guerrera
LAB HEAD: I Chiara Guerrera
PROVIDER: PXD011986 | Pride | 2019-06-05
REPOSITORIES: Pride
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Publications
Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes.
Gnangnon Bénédicte B Fréville Aline A Cailliau Katia K Cailliau Katia K Leroy Catherine C De Witte Caroline C Tulasne David D Martoriarti Alain A Jung Vincent V Guerrera Ida Chiara IC Marion Sabrina S Khalife Jamal J Pierrot Christine C
Scientific reports 20190531 1
Pseudokinases play key roles in many biological processes but they are poorly understood compared to active kinases. Eight putative pseudokinases have been predicted in Plasmodium species. We selected the unique pseudokinase belonging to tyrosine kinase like (TKL) family for detailed structural and functional analysis in P. falciparum and P. berghei. The primary structure of PfpTKL lacks residues critical for kinase activity, supporting its annotation as a pseudokinase. The recombinant pTKL pseu ...[more]
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