Ontology highlight
ABSTRACT:
INSTRUMENT(S): LCQ Classic
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Claudia Landi
LAB HEAD: Luca Bini
PROVIDER: PXD012045 | Pride | 2019-02-26
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
DNAdsRPAWT.1317.1317.2.dta | Other | |||
DNAdsRPAWT.1317.1317.2.pride.mgf.gz | Mgf | |||
DNAdsRPAWT.1581.1581.2.dta | Other | |||
DNAdsRPAWT.1581.1581.2.pride.mgf.gz | Mgf | |||
DNAdsRPAWT.RAW | Raw |
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Nucleic acids research 20190501 8
DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to maintain genome stability. DSB resection generates a single strand DNA intermediate, which is crucial for the HR process. We used a synthetic DNA structure, mimicking a resection intermediate, as a bait to identify proteins involved in this process. Among these, LC/MS analysis identified the RNA binding protein, HNRNPD. We found that HNRNPD binds chromatin, although this binding occurred independently of DNA ...[more]