Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Joern Dengjel
LAB HEAD: Joern Dengjel
PROVIDER: PXD012068 | Pride | 2019-12-04
REPOSITORIES: Pride
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20170413_ZH_AB_w_TiO2.raw | Raw | |||
20170413_ZH_AB_wo_TiO2.raw | Raw | |||
MaxQuant_Output.zip | Other | |||
Readme.txt | Txt |
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Brenna Andrea A Olejniczak Iwona I Chavan Rohit R Ripperger Jürgen A JA Langmesser Sonja S Cameroni Elisabetta E Hu Zehan Z De Virgilio Claudio C Dengjel Jörn J Albrecht Urs U
eLife 20191105
Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here, we show that the cyclin-dependent kinase 5 (CDK5) regulates the mammalian circadian clock involving phosphorylation of PER2. Knock-down of <i>Cdk5</i ...[more]