Proteomics

Dataset Information

0

Cyclin dependent kinase 5 (CDK5) regulates the circadian clock


ABSTRACT: We show that the cyclin-dependent kinase 5 (CDK5) regulates the mammalian circadian clock via phosphorylation of PER2. CDK5 phosphorylated PER2 at serine residue 394 (S394) as shown by an in vitro kinase assay.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Joern Dengjel  

LAB HEAD: Joern Dengjel

PROVIDER: PXD012068 | Pride | 2019-12-04

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20170413_ZH_AB_w_TiO2.raw Raw
20170413_ZH_AB_wo_TiO2.raw Raw
MaxQuant_Output.zip Other
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Publications


Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here, we show that the cyclin-dependent kinase 5 (CDK5) regulates the mammalian circadian clock involving phosphorylation of PER2. Knock-down of <i>Cdk5</i  ...[more]

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