Dataset Information

Proteomics of Brain Proteome Revealed Altered Mitochondrial Function in Alzheimer Disease

ABSTRACT: A discovery-driven approach with isobaric tag for relative and absolute quantitation (iTRAQ) and label-free quantitative proteomics was used to profiled the mitochondrial proteome in human brain tissues of healthy and AD individuals.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Sunil Adav

LAB HEAD: Prof Sze S K

PROVIDER: PXD012203 | Pride | 2019-02-01

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	140725_Sunil_iTRAQ_AD_01_A.raw	Raw
	140725_Sunil_iTRAQ_AD_01_B.raw	Raw
	140725_Sunil_iTRAQ_AD_01_C.raw	Raw
	140725_Sunil_iTRAQ_AD_02_A.raw	Raw
	140725_Sunil_iTRAQ_AD_02_B.raw	Raw

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Publications

Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer's disease.

Adav Sunil S SS Park Jung Eun JE Sze Siu Kwan SK Sze Siu Kwan SK

Molecular brain 20190128 1

Mitochondrial dysfunction is a key feature in both aging and neurodegenerative diseases including Alzheimer's disease (AD), but the molecular signature that distinguishes pathological changes in the AD from healthy aging in the brain mitochondria remain poorly understood. In order to unveil AD specific mitochondrial dysfunctions, this study adopted a discovery-driven approach with isobaric tag for relative and absolute quantitation (iTRAQ) and label-free quantitative proteomics, and profiled the ...[more]

PMID: 30691479

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