Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Urine
SUBMITTER: Julie Anh Dung Van
LAB HEAD: Ana Konvalinka
PROVIDER: PXD012210 | Pride | 2020-01-20
REPOSITORIES: Pride
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AdDIT_pep10_Fr1_Inj1.raw | Raw | |||
AdDIT_pep10_Fr2_Inj1.raw | Raw | |||
AdDIT_pep10_Fr3_Inj1.raw | Raw | |||
AdDIT_pep11_Fr1_Inj1.raw | Raw | |||
AdDIT_pep11_Fr2_Inj1.raw | Raw |
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Molecular & cellular proteomics : MCP 20191226 3
Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are captured by the urinary peptidome. To elucidate the early kidney response to chronic hyperglycemia, we conducted a peptidomic investigation into urines from otherwise healthy youths with type 1 diabetes and their non-diabetic peers using unbiased and targeted mass spectrometry-based techniques. This cross-sectional s ...[more]