Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Catherine Costello
LAB HEAD: Catherine E. Costello
PROVIDER: PXD012427 | Pride | 2020-06-16
REPOSITORIES: Pride
Items per page: 1 - 5 of 48 |
Structure (London, England : 1993) 20190404 6
The cellular isoform of the prion protein (PrP<sup>C</sup>) serves as precursor to the infectious isoform (PrP<sup>Sc</sup>), and as a cell-surface receptor, which binds misfolded protein oligomers as well as physiological ligands such as Cu<sup>2+</sup> ions. PrP<sup>C</sup> consists of two domains: a flexible N-terminal domain and a structured C-terminal domain. Both the physiological and pathological functions of PrP depend on intramolecular interactions between these two domains, but the spe ...[more]